Trelegy ics laba lama safety information12/17/2023 ![]() ![]() For patients who do not respond adequately to TRELEGY ELLIPTA 100/62. TRELEGY ELLIPTA 200/62.5/25 mcg should be considered for patients who require a higher dose of inhaled corticosteroid in combination with a LAMA and a LABA. Triple ICS/LABA/LAMA FDC and dual LABA/LAMA or ICS/LABA FDCs are characterized by specific efficacy/safety profiles in agreement with the level of blood eosinophil count at baseline.ĬOPD ICS LABA LAMA dual bronchodilation network meta-analysis triple therapy. low to mid dose of inhaled corticosteroid in combination with a LAMA and a LABA. Safety, tolerability and acceptability of two dry. SABA, LAMA, LABA, LAMA/LABA, ICS/LABA etc.). For such patients, single-inhaler FF/UMEC/VI is an effective treatment option with a favourable riskbenefit profile. Depending on the patient and the drug classes required (e.g. The weighted efficacy/safety profile resulting from SUCRA provided the following ranking in patients with low eosinophil count: ICS/LABA/LAMA>LABA/LAMA≫ICS/LABA whereas in patients with high eosinophil count the ranking was as follows: ICS/LABA/LAMA>LABA/LAMA>ICS/LABA FDC. In patients with uncontrolled moderate or severe asthma on ICS/LABA, adding UMEC improved lung function but did not lead to a significant reduction in moderate and/or severe exacerbations. ![]() The treatment ranking was reported via the surface under the cumulative ranking curve analysis (SUCRA).ĭata obtained from 21,909 COPD patients were extracted from the ETHOS, KRONOS, IMPACT, and TRILOGY studies, the only that fulfilled the strict inclusion criteria of this research. either dual LABA/LAMA or ICS/LABA therapies administered at fixed-dose combination (FDC) via the same inhaler device.Ī network meta-analysis was performed to assess the efficacy/safety impact of triple ICS/LABA/LAMA FDC compared with dual LABA/LAMA and ICS/LBA FDCs administered via the same inhaler device in COPD patients. The aim of this study was a quantitative synthesis by considering the studies that directly compared triple ICS/LABA/LAMA vs. A placebo-controlled trial with another LABA (salmeterol) showed an increase in asthma related deaths. Long-acting beta 2-adrenergic agonists (LABA), such as vilanterol, increase the risk of asthma-related death. In some studies comparing triple with dual combination therapies in COPD there might be a possible effect of inhaler bias resulting from different inhaler devices being used in comparator arms. ICS/LABA/LAMA treatment via the Trelegy Ellipta inhaler was more effective than dual ICS/LABA (Relvar) or LAMA/LABA. Please consult the full Prescribing Information for all the labelled safety information for Trelegy Ellipta. ![]()
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